WinPep®Sparin is an innovative peptide derived from Sphingobacterium lipoprotein, crafted using cutting-edge CADD technology. lt targets the novel soothing receptor, G protein-coupled receptor PAR-2, effectively diminishing neural sensitivity and elevating the skin's tolerance threshold, soothe, and calm the skin. And also it provides immediate relief redness through anti-inflammatory effect and strengthens the skin barrier.
Winkey Technology has developed a series of innovative peptides using cutting-edge drug development technologies, such as Computer-Aided Drug Design (CADD) and Artificial Intelligence-based Drug Design (AIDD). These advanced technologies played a pivotal role in target identification, peptide design, and structural optimization, utilizing precise simulation and predictive analysis to ensure the efficacy and stability of each peptide within specific biological pathways. Notably, these groundbreaking peptides are protected by global PCT patents.
For more information on our patented peptides, please visit: WKPep®Erasin, WKPep®Salaregen S
The Science Behind WinPep® Sparin
The journey to developing WinPep® Sparin begins with a fascinating discovery: Sphingobacterium, a unique microorganism capable of thriving in extremely arid and inhospitable environments. This resilience is due to its lipoproteins, which contain a range of distinctive proteins that allow it to survive where most other organisms would perish. These extraordinary properties provided a novel foundation for our innovative skincare solutions, inspiring us to explore how its natural resilience could benefit sensitive skin.
In our R&D laboratory, we constructed a lipoprotein model and developed a peptide library using cutting-edge CADD technology. This library includes both the full sequence of lipoproteins and various fragmented lipoprotein small molecules, offering a rich source of peptides that could potentially address skin concerns.
Once we had obtained the peptides — referred to as the “KEY”— the next challenge was to identify the corresponding “LOCK”. For this, we turned to AIDD technology, which allowed us to search for specific targets for each peptide within the library. Through virtual screening and peptide-protein (ligand-receptor) interaction prediction, we pinpointed receptors that could have a significant impact on skin sensitivity.
Among a vast amount of analytical data, PAR2, a receptor involved in skin irritation, inflammatory responses, and itching, emerged as a key target. PAR2 plays a crucial role in the skin’s reaction to sensitivity and inflammation. This discovery was pivotal, as targeting PAR2 promised to address one of the most common skin concerns: discomfort caused by inflammation and itching.
With PAR2 identified, we began refining and optimizing the peptide structure. After a series of rigorous validations and modifications, we successfully developed WinPep® Sparin, a neuromodulator that helps calm and soothe sensitive skin by targeting the PAR2 receptor.
Mechanism and Benefit
- Inhibit the activation of PAR-2.
- Increase the threshold of nociceptor, TRPV1.
- Inhibit the release of neuropeptides, substance P, CGRP.
- Relieve itching, aching and burning.
- Inhibit the activation of PAR2-AKT-NF-κB-proinflammatory cytokines pathway.
- Alleviate skin irritation, improve redness.
Find more information about WinPep® Sparin on ulprospector.
