Latest Innovation-- WKPep®Salaregen S, Inspired by the Powerful Regenerative Creature- Salamander


The skin undergoes constant change, with skin cells on a cellular level continuously shedding and unveiling fresh, newly grown cells underneath. This dynamic process enhances your skin's natural regeneration, resulting in a radiant and rejuvenated appearance.

However, as we age, this process is altered and slows down. The effects of the slowdown cause buildup and an excess of dead skin cells that can make the skin look tired, dull, and opaque. But fear not, as our latest innovation peptide, WKPep®Salaregen S, presents a surprising solution to this concern.

The breathtaking discovery of WKPep®Salaregen S

Around 400 million years ago, the first tetrapods began exploring the land during the Devonian period. As they adapted to their newfound terrestrial environment, they radiated into various branches, each with its unique set of characteristics. One group, in particular, would captivate the imagination of scientists for centuries to come—the amphibians we now know as salamanders.


Legends and tales have been woven around them, further adding to their mystique. Derived from the ancient Greek word "salamandra," meaning "fire lizard," some believed these extraordinary creatures possessed an otherworldly power—the ability to withstand fire itself and even extinguish it with their very skin secretions. Yet, as time went on, the truth prevailed, debunking this mythical notion.


What truly sets salamanders apart, however, lies within their remarkable regenerative abilities. While wound repair is an efficient process for most organisms, salamanders take it to an extraordinary level. Their regenerative prowess surpasses mere healing, extending to the astounding ability to regrow entire limbs or tails, even as juveniles.


(Picture source: Joven, A., Elewa, A., & Simon, A. (2019). Model systems for regeneration: salamanders. Development, 146.)

For centuries, scientists and researchers have been fascinated by this animal, anatomically similar to humans. Here is new hope and important insights about regeneration. Since the Enlightenment, they have delved into the depths of salamander biology, trying to uncover secrets hidden within their cellular makeup.


Recognizing the hidden potential of these ancient creatures, Winkey searched tirelessly for a substance that might be the key to unexpected skin repair and rejuvenation in salamander skin. Fortunately, a "native" peptide was identified from the skin of salamander, possessing a remarkable potential for renewal and rejuvenation. 

A successful development of WKPep®Salaregen S


Our promoting research began with the meticulous analysis of the “native” peptide's sequence, followed by its synthesis through 

chemical means as well as the efficacy and safety test. However, as with any scientific endeavor, challenges emerged along the way. 

It cannot be directly used on the skin due to various problems such as instability and immunogenicity.


To overcome these hurdles, further researches were conducted. The peptide underwent structure modification and optimization, 

leveraging state-of-the-art drug development techniques. Finally, we successfully developed and synthesized a new type of modified 

peptide, exhibiting a stable structure, remarkable efficacy, and guaranteed safety.


In honor of the inspiration of the Salamander, this new peptide is called "Salaregen S", which means salamander and regeneration.

Harmonizing with the Stages of Skin Regeneration, Anti-inflammation, Skin proliferation, Remodeling

  • Anti-inflammation, improve the red spot and soothing skin

Inhibit the production of proinflammatory cytokines, such as IL-6, IL-8, and TNF-α. Reduce the irritant by reduction for the expression of NF-κB.

  • Skin proliferation, prevent premature signs of aging

Increase the cellular viability and cells migration, effectively promote the production of collagen I.

Improve the skin elasticity and firmness, obviously reduce fine lines and wrinkles.

  • Remodeling, maintain skin barrier structural integrity, strengthen its function

Promote skin barrier related protein synthesis, loricrin and filaggrin, helps to remodel skin barrier.