What if you could help your skin live longer—healthier, stronger, and more resilient with each passing year? Modern skincare isn't just about looking good today; it's about preserving your skin's health and longevity for the long term. Innovations like AI-designed peptides are turning this vision into reality, targeting the very proteins that keep your skin firm, smooth, and youthful.
And that's where WKPep®Caffytide S comes in: a breakthrough peptide designed to defend collagen, silence hidden aging triggers, and awaken the skin's natural renewal potential.
Every great innovation begins with curiosity. Our scientists asked: what if we could quiet the enzymes that silently accelerate skin aging?
The answer began with a Hexapeptide (GPQGPQ), a tiny sequence discovered through advanced CADD technology. This peptide contains the similar structure that MMP2 naturally recognizes, allowing it to help control the enzyme's activity. MMP2 is an enzyme notorious for breaking down collagen and weakening the dermal-epidermal junction (DEJ).
To amplify its potential, we turned to caffeic acid, a natural antioxidant celebrated for its protective power and ability to inhibit UVA-induced MMPs. Caffeic acid's instability, however, has limited its use in skincare. Through Peptide-Drug Conjugate (PDC) technology, caffeic acid and GPQGPQ were covalently bound, creating a new entity: Caffeoyl Hexapeptide-9.
With the help of AI and molecular docking, this fusion revealed an even stronger bond to MMP2 than Hexapeptide (GPQGPQ), unlocking a new way to defend skin structure, protect collagen, and empower long-term renewal.
Silences MMP2
Inhibits MMP2 production and activity, defends against enzymatic collagen breakdown, slowing structural decline.
Strengthens the DEJ
Improves cohesion between epidermis and dermis, enhancing resilience.
Boosts Structural Proteins
Stimulates Collagen I, III, IV and Laminins, vital for firmness and elasticity.
Antioxidant Power
Protects against free radical damage, amplifying skin's defense system.
In vitro
- Reduced MMP2 expression by 54.9% after UV exposure—outperforming Hexapeptide-9.
- Boosted Collagen I, III, IV and Laminin production, with Collagen IV and Laminin showing superior results compared to Retinol.
In vivo
- Wrinkle reduction in just 14 days, with continued improvement by day 28.
- Firmness & elasticity increased by over 30% in 28 days, significantly higher than retinol.
- Dark circles diminished visibly in 28 days, restoring brightness and vitality.
WKPep®Caffytide S represents the meeting of AI precision, CADD Technology, and molecular design. More than a breakthrough, it's a story of how science can reshape beauty—helping skin stay youthful, strong, and radiant for years to come.
Find more information about WKPep®Caffytide S on ulprospector.