Does your skin react to the slightest change, leaving you red, itchy, or uncomfortable? Sensitive skin requires more than just barrier repair—it demands care at a deeper, sensory level. Neurocosmetics, an emerging field in skincare, focuses on understanding and addressing the intricate connection between the skin and the nervous system. This article explores how neurocosmetics can help calm irritation and provide targeted relief for sensitive skin.

What Are Neurocosmetics?

Neurocosmetics represent a specialized category of skincare products designed to interact with the skin's nervous system. By modulating the signals between the skin and the brain, these products deliver targeted benefits such as calming irritation, reducing stress-induced damage, and enhancing sensory comfort.

The skin, one of the body’s largest organs, functions as more than a protective barrier. It is a dynamic sensory network with its own immune responses and an extensive system of nerve cells that communicate directly with the brain. This connection enables the skin to respond to external stimuli, but for many individuals, these responses become overactive, leading to sensitivity, redness, and irritation.

Key Receptors in Sensitive Skin: TRPV-1 and PAR-2

The skin is a neuro-sensory organ with nerve endings equipped with receptors that regulate sensitivity. Two key receptors—TRPV-1 (Transient Receptor Potential Vanilloid 1) and PAR-2 (Protease-Activated Receptor 2)—play pivotal roles in skin sensitivity and are central to neurocosmetics. These receptors influence the release of neuropeptides like CGRP (Calcitonin Gene-Related Peptide) and Substance P, which contribute to neurogenic inflammation and discomfort.

TRPV-1: The Skin's Heat and Pain Sensor

• TRPV-1 responds to heat, acidity, and certain chemical irritants, triggering sensations such as burning, stinging, or itching.

• When activated, TRPV-1 stimulates the release of neuropeptides like Substance P and CGRP, which amplify inflammation, vasodilation, and discomfort.

• In sensitive skin, TRPV-1 can become hyperactive, leading to exaggerated responses to even mild stimuli.

PAR-2: The Itch and Inflammation Mediator

• PAR-2 is another key receptor involved in skin sensitivity, particularly in triggering inflammatory and itching responses.

• Activation of PAR-2 triggers the release of neuropeptides, intensifying itch and inflammation.

• Additionally, PAR-2 activation stimulates CGRP, which exacerbates neurogenic inflammation by increasing blood flow and promoting redness.

Winkey Advanced Ingredients in Neurocosmetics

WinPep® Sparin: Innovative neuropeptide 

WinPep® Sparin is a patented neuropeptide that soothes sensitive skin by inhibiting PAR-2 activation and increasing the TRPV-1 threshold. Harnessing the resilience of microbial energy thriving in extreme environments, it is meticulously crafted through cutting-edge CADD technology and inspired by the remarkable properties of Sphingobacterium lipoprotein.

• Targeted Action: It modulates the G protein-coupled receptor PAR-2, reducing neural sensitivity and enhancing the skin’s tolerance threshold.

• Visible Benefits: Rapidly alleviates redness, calms irritation, and fortifies the skin barrier.

• Recognition: In 2024, it was shortlisted for the “Innovation Zone Best Ingredient Awards 2024 Active Ingredient” at in-cosmetics Latin America.

WActive® Tri-Calmin: A Sustainable Soothing Solution

WActive® Tri-Calmin is a waterless, sustainable solution derived from Rhodiola Rosea, Olea Europaea, and Gentiana Scabra, responsibly sourced from altitudes ranging from 4,000 meters to 300 meters. Inspired by the biodiversity of Chinese flora, this ingredient targets multiple pathways to calm sensitive skin.

• Mechanism of Action: Mitigates Ca2+ influx and intercepts action potentials, alleviating sensations of pain and itch caused by TRPV-1 activation.

• Anti-Inflammatory Benefits: Reduces redness and inflammation by targeting mediators like LTB4 and COX2.

• Comprehensive Care: Fortifies the skin against environmental stressors, promoting stability and unveiling a revitalized complexion.